产品名称
Rho GDIγ Rabbit Polyclonal Antibody
别名
ARHGDIG; Rho GDP-dissociation inhibitor 3; Rho GDI 3; Rho-GDI gamma
蛋白名称
Rho GDP-dissociation inhibitor 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=398
Human Swissprot No.
Q99819
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99819/entry
Mouse Swissprot No.
Q62160
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q62160
免疫原
Synthesized peptide derived from Rho GDIγ . at AA range: 110-190
特异性
Rho GDIγ Polyclonal Antibody detects endogenous levels of Rho GDIγ protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010],
组织表达
Primarily expressed in pancreas and brain.
功能
function:Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.,similarity:Belongs to the Rho GDI family.,tissue specificity:Primarily expressed in pancreas and brain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
