产品名称
Rho D Rabbit Polyclonal Antibody
别名
RHOD; ARHD; Rho-related GTP-binding protein RhoD; Rho-related protein HP1; RhoHP1
蛋白名称
Rho-related GTP-binding protein RhoD
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29984
Human Swissprot No.
O00212
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O00212/entry
Mouse Swissprot No.
P97348
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97348
免疫原
The antiserum was produced against synthesized peptide derived from human RHOD. AA range:113-162
特异性
Rho D Polyclonal Antibody detects endogenous levels of Rho D protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],
组织表达
Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.
细胞定位
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Early endosome . Colocalizes with RAB5 to early endosomes (By similarity). .
功能
function:Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Participates in reorganization of actin cytoskeleton.,similarity:Belongs to the small GTPase superfamily. Rho family.,subunit:In the GTP-bound form, interacts with DIAPH2 isoform 3.,tissue specificity:Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
