产品名称
RGS5 Rabbit Polyclonal Antibody
别名
RGS5; Regulator of G-protein signaling 5; RGS5
蛋白名称
Regulator of G-protein signaling 5
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8490
Human Swissprot No.
O15539
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O15539/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19737
Mouse Swissprot No.
O08850
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O08850
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54294
Rat Swissprot Link
http://www.uniprot.org/uniprot/P49800
免疫原
The antiserum was produced against synthesized peptide derived from human RGS5. AA range:89-138
特异性
RGS5 Polyclonal Antibody detects endogenous levels of RGS5 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011],
组织表达
Aorta,Brain,Human cervix,Liver,Neuroblastoma,Normal aorta,
细胞定位
[Isoform 1]: Cytoplasm . Membrane .; [Isoform 2]: Cytoplasm .
功能
function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.,similarity:Contains 1 RGS domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
