产品名称
KLK10 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/5655
Human Swissprot No.
O43240
Human Swissprot Link
https://www.uniprot.org/uniprotkb/O43240/entry
Rat Gene Link
https://www.uniprot.org/uniprot/100911689
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P36375
免疫原
Synthesized peptide derived from human KLK10 AA range: 199-249
特异性
This antibody detects endogenous levels of KLK10 at Human/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its encoded protein is secreted and may play a role in suppression of tumorigenesis in breast and prostate cancers. Alternate splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008],
组织表达
Expressed in breast, ovary and prostate.
功能
developmental stage:Down-regulated during breast cancer progression.,function:Has a tumor-suppressor role for NES1 in breast and prostate cancer.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,tissue specificity:Expressed in breast, ovary and prostate.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
