产品名称
RGS12 Rabbit Polyclonal Antibody
别名
RGS12; Regulator of G-protein signaling 12; RGS12
蛋白名称
Regulator of G-protein signaling 12
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6002
Human Swissprot No.
O14924
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O14924/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71729
Mouse Swissprot No.
Q8CGE9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CGE9
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54292
Rat Swissprot Link
http://www.uniprot.org/uniprot/O08774
免疫原
The antiserum was produced against synthesized peptide derived from human RGS12. AA range:141-190
特异性
RGS12 Polyclonal Antibody detects endogenous levels of RGS12 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the 'regulator of G protein signaling' (RGS) gene family. The encoded protein may function as a guanosine triphosphatase (GTPase)-activating protein as well as a transcriptional repressor. This protein may play a role in tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008],
组织表达
Isoform 3 is brain specific.
细胞定位
Nucleus . Cytoplasm . Cell projection, dendrite . Cell junction, synapse .; [Isoform 5]: Nucleus matrix . Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains. .
功能
function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 GoLoco domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 PID domain.,similarity:Contains 1 RGS domain.,similarity:Contains 2 RBD (Ras-binding) domains.,tissue specificity:Isoform 3 is brain specific.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
