BD-PT4070

RGS1 Rabbit Polyclonal Antibody

RGS1; 1R20; BL34; IER1; Regulator of G-protein signaling 1; RGS1; B-cell activation protein BL34; Early response protein 1R20

常规抗体

RGS1

Regulator of G-protein signaling 1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

5996

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5996

Q08116

http://www.uniprot.org/uniprotkb/Q08116/entry

50778

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50778

Q9JL25

http://www.uniprot.org/uniprot/Q9JL25

54289

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54289

P97844

http://www.uniprot.org/uniprot/P97844

The antiserum was produced against synthesized peptide derived from human RGS1. AA range:118-167

RGS1 Polyclonal Antibody detects endogenous levels of RGS1 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

22kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008],

Detected in peripheral blood monocytes (PubMed:10480894). Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738).

Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytosol .

function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation.,induction:In response to several B-cell activation signals.,PTM:Could be phosphorylated. Might be functionally regulated by protein kinase(s).,similarity:Contains 1 RGS domain.,tissue specificity:B-cell specific. Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B-cell such as non-Hodgkin's lymphoma and hairy cell leukemia, expression is constitutively high.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.