产品名称
Repetin Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=126638
Human Swissprot No.
Q6XPR3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6XPR3/entry
Mouse Swissprot No.
P97347
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P97347
免疫原
The antiserum was produced against synthesized peptide derived from human RPTN. AA range:648-697
特异性
Repetin Polyclonal Antibody detects endogenous levels of Repetin protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
domain:Can be divided into a N-terminal domain with significant homology to S100-like calcium-binding proteins, a central domain containing a series of short tandem repeats, and two flanking segments with low homology to the consensus sequences of the central repeats.,function:Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Potential substrate of transglutaminase. Some arginines are probably converted to citrullines by peptidylarginine deimidase.,similarity:Belongs to the S100-fused protein family.,similarity:Contains 2 EF-hand domains.,tissue specificity:Expression is scattered in the normal epidermis but strong in the acrosyringium, the inner hair root sheat and in the filiform papilli of the tongue.,
组织表达
Expression is scattered in the normal epidermis but strong in the acrosyringium, the inner hair root sheath and in the filiform papilli of the tongue.
细胞定位
Secreted, extracellular space, extracellular matrix.
功能
domain:Can be divided into a N-terminal domain with significant homology to S100-like calcium-binding proteins, a central domain containing a series of short tandem repeats, and two flanking segments with low homology to the consensus sequences of the central repeats.,function:Involved in the cornified cell envelope formation. Multifunctional epidermal matrix protein. Reversibly binds calcium.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Potential substrate of transglutaminase. Some arginines are probably converted to citrullines by peptidylarginine deimidase.,similarity:Belongs to the S100-fused protein family.,similarity:Contains 2 EF-hand domains.,tissue specificity:Expression is scattered in the normal epidermis but strong in the acrosyringium, the inner hair root sheat and in the filiform papilli of the tongue.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
