产品名称
REP-2 Rabbit Polyclonal Antibody
别名
CHML; REP2; Rab proteins geranylgeranyltransferase component A 2; Choroideraemia-like protein; Rab escort protein 2; REP-2
蛋白名称
Rab proteins geranylgeranyltransferase component A 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1122
Human Swissprot No.
P26374
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P26374/entry
Mouse Swissprot No.
Q9QZD5
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9QZD5
免疫原
The antiserum was produced against synthesized peptide derived from human CHML. AA range:128-177
特异性
REP-2 Polyclonal Antibody detects endogenous levels of REP-2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. [provided by RefSeq, Jul 2008],
细胞定位
Cytoplasm, cytosol .
功能
function:Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than REP-1 in supporting prenylation of Rab3 family.,miscellaneous:Substitutes for REP-1 thereby preventing widespread tissue abnormalities in patients with choroideremia who lack REP-1.,similarity:Belongs to the Rab GDI family.,subunit:Monomer. Interacts with Rab and Rab GGTase.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
