产品名称
Renin Rabbit Polyclonal Antibody
别名
REN; Renin; Angiotensinogenase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5972
Human Swissprot No.
P00797
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P00797/entry
免疫原
The antiserum was produced against synthesized peptide derived from human REN. AA range:207-256
特异性
Renin Polyclonal Antibody detects endogenous levels of Renin protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008],
组织表达
Colon,Fetal liver,Ovary,
细胞定位
Secreted. Membrane. Associated to membranes via binding to ATP6AP2.
信号通路
Renin-angiotensin system;
功能
catalytic activity:Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.,disease:Defects in REN are a cause of renal tubular dysgenesis (RTD) [MIM:267430]. RTD is an autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).,enzyme regulation:Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing.,function:Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney.,online information:Renin entry,similarity:Belongs to the peptidase A1 family.,subcellular location:Associated to membranes via binding to ATP6AP2.,subunit:Interacts with ATP6AP2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
