产品名称
RBAK Rabbit Polyclonal Antibody
别名
RBAK; ZNF769; RB-associated KRAB zinc finger protein; RB-associated KRAB repressor; hRBaK; Zinc finger protein 769
蛋白名称
RB-associated KRAB zinc finger protein
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57786
Human Swissprot No.
Q9NYW8
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NYW8/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57782
Mouse Swissprot No.
Q8BQC8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BQC8
免疫原
The antiserum was produced against synthesized peptide derived from human RBAK. AA range:1-50
特异性
RBAK Polyclonal Antibody detects endogenous levels of RBAK protein.
稀释度
WB 1:500-2000; IF ICC 1:50-200;ELISA 1:2000-20000;IHC-p 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011],
组织表达
Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.
功能
function:May repress E2F-dependent transcription. May promote AR-dependent transcription.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 1 KRAB domain.,similarity:Contains 16 C2H2-type zinc fingers.,subunit:Interacts with AR and RB1. May also interact with other nuclear hormone receptors such as NR3C1/GR.,tissue specificity:Expressed in bone, brain, heart, kidney, liver, lung, pancreas and placenta.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
