产品名称
RASSF6 Rabbit Polyclonal Antibody
别名
RASSF6; Ras association domain-containing protein 6
蛋白名称
Ras association domain-containing protein 6
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=166824
Human Swissprot No.
Q6ZTQ3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q6ZTQ3/entry
Mouse Swissprot No.
Q80UQ2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q80UQ2
免疫原
The antiserum was produced against synthesized peptide derived from human RASSF6. AA range:129-178
特异性
RASSF6 Polyclonal Antibody detects endogenous levels of RASSF6 protein.
稀释度
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012],
组织表达
Highest expression in thymus, kidney and placenta. Also detected in colon, small intestine and lung. Tends to be down-regulated in 30-60% of tumors derived from breast, colon, kidney liver, rectum, pancreas, stomach and the thyroid gland compared to the normal counterpart.
功能
function:May act as a Ras effector protein.,sequence caution:Translated as Gln.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 SARAH domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
