产品名称
RAP1 Rabbit Polyclonal Antibody
别名
TERF2IP; DRIP5; RAP1; PP8000; Telomeric repeat-binding factor 2-interacting protein 1; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homol
蛋白名称
Telomeric repeat-binding factor 2-interacting protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54386
Human Swissprot No.
Q9NYB0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NYB0/entry
Mouse Swissprot No.
Q91VL8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91VL8
免疫原
The antiserum was produced against synthesized peptide derived from human RAP1. AA range:203-252
特异性
RAP1 Polyclonal Antibody detects endogenous levels of RAP1 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010],
组织表达
Ubiquitous. Highly expressed.
细胞定位
Nucleus . Cytoplasm . Chromosome . Chromosome, telomere . Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex. .
信号通路
B_Cell_Antigen; Adherens_Junction
功能
function:May play a role in telomere length regulation. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.,miscellaneous:Recruited to telomeres by TRF2; seemingly it does not directly bind to DNA itself.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translated as Glu.,similarity:Contains 1 BRCT domain.,similarity:Contains 1 Myb-like domain.,subcellular location:Colocalizes with telomeric DNA in interphase and metaphase cells.,subunit:Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Binds to TRF2 (but not TRF1) with its C-terminus.,tissue specificity:Ubiquitous. Highly expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
