产品名称
DSE Rabbit Polyclonal Antibody
别名
Dermatan-sulfate epimerase (DS epimerase) (EC 5.1.3.19) (Chondroitin-glucuronate 5-epimerase) (Squamous cell carcinoma antigen recognized by T-cells 2) (SART-2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.249% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/29940
Human Swissprot No.
Q9UL01
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9UL01/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/212898
Mouse Swissprot No.
Q8BLI4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BLI4
免疫原
Synthesized peptide derived from human DSE AA range: 164-214
特异性
This antibody detects endogenous levels of DSE at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016],
组织表达
Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level).
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein .
功能
catalytic activity:Chondroitin D-glucuronate = dermatan L-iduronate.,function:Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues.,pathway:Glycan metabolism; chondroitin sulfate biosynthesis.,pathway:Glycan metabolism; heparan sulfate biosynthesis.,similarity:Belongs to the dermatan-sulfate isomerase family.,tissue specificity:Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
