产品名称
Ran BP-17 Rabbit Polyclonal Antibody
别名
RANBP17; Ran-binding protein 17
蛋白名称
Ran-binding protein 17
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64901
Human Swissprot No.
Q9H2T7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H2T7/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66011
Mouse Swissprot No.
Q99NF8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99NF8
免疫原
The antiserum was produced against synthesized peptide derived from human RANBP17. AA range:145-194
特异性
Ran BP-17 Polyclonal Antibody detects endogenous levels of Ran BP-17 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
RAN binding protein 17(RANBP17) Homo sapiens The transport of protein and large RNAs through the nuclear pore complexes (NPC) is an energy-dependent and regulated process. The import of proteins with a nuclear localization signal (NLS) is accomplished by recognition of one or more clusters of basic amino acids by the importin-alpha/beta complex; see MIM 600685 and MIM 602738. The small GTPase RAN (MIM 601179) plays a key role in NLS-dependent protein import. RAN-binding protein-17 is a member of the importin-beta superfamily of nuclear transport receptors.[supplied by OMIM, Jul 2002],
组织表达
Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.
细胞定位
Cytoplasm . Nucleus . Nucleus, nuclear pore complex .
功能
function:May function as a nuclear transport receptor.,similarity:Belongs to the exportin family.,subunit:Binds to nucleoporins and the GTP-bound form of Ran.,tissue specificity:Highly expressed in testis, moderately in pancreas and weakly in other tissues studied.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
