产品名称
RAGE Rabbit Polyclonal Antibody
别名
MOK; RAGE; RAGE1; MAPK/MAK/MRK overlapping kinase; MOK protein kinase; Renal tumor antigen 1; RAGE-1
蛋白名称
MAPK/MAK/MRK overlapping kinase
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5891
Human Swissprot No.
Q9UQ07
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9UQ07/entry
Mouse Swissprot No.
Q9WVS4
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9WVS4
免疫原
The antiserum was produced against synthesized peptide derived from human MOK. AA range:261-310
特异性
RAGE Polyclonal Antibody detects endogenous levels of RAGE protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
MOK protein kinase(MOK) Homo sapiens This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012],
组织表达
Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.
细胞定位
Cytoplasm . Cell projection, cilium . Nucleus .
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Phosphorylation appears to increase the enzymatic activity.,function:Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed in heart, brain, lung, kidney, and pancreas, and at very low levels in placenta, liver and skeletal muscle. Detected in retina.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
