产品名称
Rag C Rabbit Polyclonal Antibody
别名
RRAGC; Ras-related GTP-binding protein C; Rag C; RagC; GTPase-interacting protein 2; TIB929
蛋白名称
Ras-related GTP-binding protein C
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64121
Human Swissprot No.
Q9HB90
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9HB90/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54170
Mouse Swissprot No.
Q99K70
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99K70
免疫原
The antiserum was produced against synthesized peptide derived from human RRAGC. AA range:302-351
特异性
Rag C Polyclonal Antibody detects endogenous levels of Rag C protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; IP 1:50-200 ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012],
细胞定位
Cytoplasm . Nucleus . Lysosome . Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA (PubMed:11073942). .
功能
function:Has guanine nucleotide-binding activity but weak intrinsic GTPase activity.,similarity:Belongs to the GTR/RAG GTP-binding protein family.,subcellular location:Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA.,subunit:Forms a heterodimer with RRAGA in a sequence-independent manner. Binds GTP. Interacts with NOL8 and RRAGB.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.