产品名称
Rad23A Rabbit Polyclonal Antibody
别名
RAD23A; UV excision repair protein RAD23 homolog A; HR23A; hHR23A
蛋白名称
UV excision repair protein RAD23 homolog A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5886
Human Swissprot No.
P54725
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P54725/entry
Mouse Swissprot No.
P54726
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P54726
免疫原
The antiserum was produced against synthesized peptide derived from human RAD23A. AA range:91-140
特异性
Rad23A Polyclonal Antibody detects endogenous levels of Rad23A protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012],
组织表达
Brain,Pancreas,Testis,
信号通路
Nucleotide excision repair;
功能
domain:The ubiquitin-like domain mediates interaction with MJD.,function:Involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA .,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the RAD23 family.,similarity:Contains 1 ubiquitin-like domain.,similarity:Contains 2 UBA domains.,subunit:Interacts with MJD. Interacts with HIV-1 Vpr.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
