产品名称
Rabphilin-3A Rabbit Polyclonal Antibody
别名
RPH3A; KIAA0985; Rabphilin-3A; Exophilin-1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22895
Human Swissprot No.
Q9Y2J0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9Y2J0/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19894
Mouse Swissprot No.
P47708
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P47708
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171039
Rat Swissprot Link
http://www.uniprot.org/uniprot/P47709
免疫原
The antiserum was produced against synthesized peptide derived from human Rabphilin 3A. AA range:203-252
特异性
Rabphilin-3A Polyclonal Antibody detects endogenous levels of Rabphilin-3A protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
Exocytosis of neurotransmitters and hormones is fundamental to synaptic neurotransmission and cell-cell communication. RAB3A (MIM 179390) is a small G protein that is thought to act at late stages of exocytosis, and RPH3A is a RAB3A effector (Lin et al., 2007 [PubMed 17149709]).[supplied by OMIM, Jul 2008],
细胞定位
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Cell projection, dendritic spine . Cell junction, synapse, postsynaptic cell membrane . Membrane ; Peripheral membrane protein .
功能
function:Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 RabBD (Rab-binding) domain.,similarity:Contains 2 C2 domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
