产品名称
Rab11-FIP4 Rabbit Polyclonal Antibody
别名
RAB11FIP4; ARFO2; KIAA1821; Rab11 family-interacting protein 4; FIP4-Rab11; Rab11-FIP4; Arfophilin-2
蛋白名称
Rab11 family-interacting protein 4
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84440
Human Swissprot No.
Q86YS3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q86YS3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=268451
Mouse Swissprot No.
Q8BQP8
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BQP8
免疫原
The antiserum was produced against synthesized peptide derived from human RAB11FIP4. AA range:452-501
特异性
Rab11-FIP4 Polyclonal Antibody detects endogenous levels of Rab11-FIP4 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP4 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Apr 2008],
组织表达
Present at high level in testis (at protein level). Weakly expressed in other tissues.
细胞定位
Endosome . Cytoplasm, cytoskeleton, spindle . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Recycling endosome membrane ; Peripheral membrane protein. Cleavage furrow . Midbody . Cytoplasmic vesicle . Recruited to the cleavage furrow and the midbody during cytokinesis. .
功能
function:A Rab11 effector protein acting in the endosomal trafficking.,similarity:Contains 1 EF-hand domain.,subcellular location:Colocalizes with RAB11A in the endocytic recycling compartment (ERC).,subunit:Homooligomer. Forms an heterooligomeric complex with RAB11FIP2, RAB11FIP3 and RAB11FIP5. Interacts with RAB11A that has been activated by GTP binding.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
