产品名称
Rab 6C Rabbit Polyclonal Antibody
别名
RAB6C; WTH3; Ras-related protein Rab-6C; Rab6-like protein WTH3
蛋白名称
Ras-related protein Rab-6C
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84084
Human Swissprot No.
Q9H0N0
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H0N0/entry
免疫原
The antiserum was produced against synthesized peptide derived from human RAB6C. AA range:165-214
特异性
Rab 6C Polyclonal Antibody detects endogenous levels of Rab 6C protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the small GTPase superfamily. Rab family.,subunit:Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Isoform 1 interacts with RAB6KIFL but not isoform 2. Isoforms 1 and 2 interact with BICD1 and BICD2. Interacts with TMF1.,tissue specificity:Ubiquitous.,
组织表达
Highest levels are found in fetal and adult brain, prostate, testis and spinal cord. Undetectable expression in adrenal gland, skeletal muscle, bone marrow, fetal, and adult liver, heart, salivary gland, and trachea. Detected in the HEK293, HEK293T, LNCaP, MCF-7, T-47D and EVSA-T cell lines (at protein level).
细胞定位
Nucleus . Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome .
功能
function:Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the small GTPase superfamily. Rab family.,subunit:Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Isoform 1 interacts with RAB6KIFL but not isoform 2. Isoforms 1 and 2 interact with BICD1 and BICD2. Interacts with TMF1.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
