产品名称
Rab 6A Rabbit Polyclonal Antibody
别名
RAB6A; RAB6; Ras-related protein Rab-6A; Rab-6
蛋白名称
Ras-related protein Rab-6A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5870
Human Swissprot No.
P20340
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P20340/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19346
Mouse Swissprot No.
P35279
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P35279
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9WVB1
免疫原
The antiserum was produced against synthesized peptide derived from human RAB6A. AA range:113-162
特异性
Rab 6A Polyclonal Antibody detects endogenous levels of Rab 6A protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011],
细胞定位
Golgi apparatus membrane ; Lipid-anchor . BICD2 facilitates its targeting to Golgi apparatus membrane. .; [Isoform 1]: Golgi apparatus membrane ; Lipid-anchor .; [Isoform 2]: Golgi apparatus membrane ; Lipid-anchor .
功能
function:Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the small GTPase superfamily. Rab family.,subunit:Interacts with SCYL1BP1. Interacts with VSP52 and RABGAP1. Isoform 1 interacts with RAB6KIFL but not isoform 2. Isoforms 1 and 2 interact with BICD1 and BICD2. Interacts with TMF1.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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