产品名称
Rab 3 GAP p150 Rabbit Polyclonal Antibody
别名
RAB3GAP2; KIAA0839; Rab3 GTPase-activating protein non-catalytic subunit; RGAP-iso; Rab3 GTPase-activating protein 150 kDa subunit; Rab3-GAP p150; Rab3-GAP150; Rab3-GAP regulatory subunit
蛋白名称
Rab3 GTPase-activating protein non-catalytic subunit
反应种属
Human,Mouse,Rat,Monkey
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25782
Human Swissprot No.
Q9H2M9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9H2M9/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=98732
Mouse Swissprot No.
Q8BMG7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BMG7
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=289350
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q5U1Z0
免疫原
The antiserum was produced against synthesized peptide derived from human RAB3GAP2. AA range:417-466
特异性
Rab 3 GAP p150 Polyclonal Antibody detects endogenous levels of Rab 3 GAP p150 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome.[provided by RefSeq, Oct 2009],
细胞定位
Cytoplasm. In neurons, it is enriched in the synaptic soluble fraction.
功能
disease:Defects in RAB3GAP2 are the cause of Martsolf syndrome [MIM:212720]. Martsolf syndrome is characterized by congenital cataracts, mental retardation, and hypogonadism. Inheritance is autosomal recessive.,function:Regulatory subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Rab3 GTPase-activating complex specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters.,similarity:Belongs to the Rab3-GAP regulatory subunit family.,subcellular location:In neurons, it is enriched in the synaptic soluble fraction.,subunit:The Rab3 GTPase-activating complex is a heterodimer composed of RAB3GAP and RAB3-GAP150. The Rab3 GTPase-activating complex interacts with DMXL2.,tissue specificity:Ubiquitous.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
