产品名称
Rab 2B Rabbit Polyclonal Antibody
别名
RAB2B; Ras-related protein Rab-2B
蛋白名称
Ras-related protein Rab-2B
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84932
Human Swissprot No.
Q8WUD1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8WUD1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76338
Mouse Swissprot No.
P59279
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P59279
免疫原
The antiserum was produced against synthesized peptide derived from human RAB2B. AA range:103-152
特异性
Rab 2B Polyclonal Antibody detects endogenous levels of Rab 2B protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006],
组织表达
Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.
细胞定位
Cell membrane ; Lipid-anchor ; Cytoplasmic side . Endoplasmic reticulum membrane ; Lipid-anchor . Golgi apparatus membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle, acrosome . Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid. .
功能
function:Required for protein transport from the endoplasmic reticulum to the Golgi complex .,similarity:Belongs to the small GTPase superfamily. Rab family.,tissue specificity:Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
