产品名称
QM Rabbit Polyclonal Antibody
别名
RPL10; DXS648E; QM; 60S ribosomal protein L10; Laminin receptor homolog; Protein QM; Tumor suppressor QM
蛋白名称
60S ribosomal protein L10
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6134
Human Swissprot No.
P27635
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P27635/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=110954
Mouse Swissprot No.
Q6ZWV3
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q6ZWV3
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81764
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6PDV7
免疫原
The antiserum was produced against synthesized peptide derived from human 60S Ribosomal Protein L10. AA range:1-50
特异性
QM Polyclonal Antibody detects endogenous levels of QM protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],
组织表达
Brain,Human lung,Mammary cancer,Mammary gland,Ovarian carcinoma,Pancreatic cancer,P
细胞定位
endoplasmic reticulum,cytosol,ribosome,membrane,cytosolic large ribosomal subunit,
功能
developmental stage:Down-regulated during adipocyte, kidney, and heart differentiation.,disease:Defects in RPL10 may be the cause of susceptibility to X-linked autism [MIM:209850]. Autism is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age.,similarity:Belongs to the ribosomal protein L10e family.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
