产品名称
RRP44 Rabbit Polyclonal Antibody
别名
Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.250% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/22894
Human Swissprot No.
Q9Y2L1
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Y2L1/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/72662
Mouse Swissprot No.
Q9CSH3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CSH3
免疫原
Synthesized peptide derived from human RRP44 AA range: 262-312
特异性
This antibody detects endogenous levels of RRP44 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
细胞定位
Cytoplasm . Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus . Predominantly located in the nucleus (PubMed:20531386). According to PubMed:12429849, found in the nucleolus (PubMed:12429849). According to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3 (PubMed:20531386). .
功能
function:Component of the exosome 3'->5' exoribonuclease complex. Required for the 3'-processing of the 7S pre-RNA to the mature nuclear complex. Also associated with the GTPase Ran. Has a 3'-5' exonuclease activity.,similarity:Belongs to the ribonuclease II (RNB) family.,similarity:Contains 1 PINc domain.,subunit:Component of the exosome multienzyme ribonuclease complex composed of at least 11 proteins: RRP4, RRP40, RRP41/SKI6, RRP42, RRP43, RRP44/DIS3, PM/Scl-75, RRP46, CSL4 and PM/Scl-100 (only in the nuclear complex). Also associated with the GTPase Ran.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
