BD-PT3908

Puratrophin 1 Rabbit Polyclonal Antibody

PLEKHG4; PRTPHN1; Puratrophin-1; Pleckstrin homology domain-containing family G member 4; PH domain-containing family G member 4; Purkinje cell atrophy-associated protein 1

常规抗体

PLEKHG4

Puratrophin-1

WB

Human,Monkey

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

25894

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25894

Q58EX7

http://www.uniprot.org/uniprotkb/Q58EX7/entry

The antiserum was produced against synthesized peptide derived from human PLEKHG4. AA range:654-703

Puratrophin 1 Polyclonal Antibody detects endogenous levels of Puratrophin 1 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

135kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene can function as a guanine nucleotide exchange factor (GEF) and may play a role in intracellular signaling and cytoskeleton dynamics at the Golgi apparatus. Polymorphisms in the region of this gene have been found to be associated with spinocerebellar ataxia in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015],

Expressed in kidney, Leydig cells in the testis, epithelial cells in the prostate gland and Langerhans islet in the pancreas. Isoform 1 and isoform 3 are strongly expressed in Purkinje cells and to a lower extent in other neurons (at protein level). Widely expressed at low levels. More strongly expressed in testis and pancreas.

disease:Defects in PLEKHG4 are the cause of spinocerebellar ataxia 16q22-linked (SCA16q22) [MIM:117210]; alo known as pure spinocerebellar ataxia Japanese type or SCA4 pure Japanese type. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA16q22 belongs to the autosomal dominant cerebellar ataxias type III (ADCA III) which are characterized by pure cerebellar ataxia without additional signs.,function:Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,tissue specificity:Expressed in kidney, Leydig cells in the testis, epithelial cells in the prostate gland and Langerhans islet in the pancreas. Isoform 1 and isoform 3 are strongly expressed in Purkinje cells and to a lower extent in other neurons (at protein level). Widely expressed at low levels. More strongly expressed in testis and pancreas.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.