产品名称
PUMA Rabbit Polyclonal Antibody
别名
BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis
蛋白名称
Bcl-2-binding component 3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27113
Human Swissprot No.
Q9BXH1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9BXH1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170770
Mouse Swissprot No.
Q99ML1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q99ML1
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=317673
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q80ZG6
免疫原
The antiserum was produced against synthesized peptide derived from human PUMA. AA range:120-169
特异性
PUMA Polyclonal Antibody detects endogenous levels of PUMA protein.
稀释度
WB 1:500-2000 IF 1:100-300 ELISA 1:5000-20000 Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011],
组织表达
Ubiquitously expressed.
细胞定位
Mitochondrion . Localized to the mitochondria in order to induce cytochrome c release.
信号通路
p53;Huntington's disease;
功能
function:Essential mediator of p53-dependent and p53-independent apoptosis.,induction:By DNA damage, glucocorticoid treatment, growth factor deprivation and p53.,similarity:Belongs to the Bcl-2 family.,subcellular location:Localized to the mitochondria in order to induce cytochrome c release.,subunit:Interacts with MCL1 and BCL2A1 (By similarity). Interacts with BCL2 and BCL2L1/BCL-XL.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
