BD-PT3921

Rab 1B Rabbit Polyclonal Antibody

RAB1B; Ras-related protein Rab-1B

常规抗体

RAB1B

Ras-related protein Rab-1B

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

81876

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=81876

Q9H0U4

http://www.uniprot.org/uniprotkb/Q9H0U4/entry

76308

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76308

Q9D1G1

http://www.uniprot.org/uniprot/Q9D1G1

P10536

http://www.uniprot.org/uniprot/P10536

Synthesized peptide derived from Rab 1B . at AA range: 50-130

Rab 1B Polyclonal Antibody detects endogenous levels of Rab 1B protein.

WB 1:500-2000

22kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009],

B-cell lymphoma,Brain,Muscle,Pancreas,

Cytoplasm . Membrane ; Lipid-anchor ; Cytoplasmic side . Preautophagosomal structure membrane ; Lipid-anchor ; Cytoplasmic side . Cytoplasm, perinuclear region . Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments (PubMed:11389151). In the GDP-form, colocalizes with GDI in the cytoplasm (PubMed:11389151). Co-localizes with MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity). .

function:Protein transport. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments.,miscellaneous:Rab-1B binds GTP and GDP and possesses intrinsic GTPase activity.,PTM:Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).,similarity:Belongs to the small GTPase superfamily. Rab family.,subcellular location:Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm.,subunit:Interacts with MICAL1, MICAL2 and MICAL3. Interacts with GDI1; the interaction requires the GDP-bound state. Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.