产品名称
PXR Rabbit Polyclonal Antibody
别名
NR1I2; PXR; Nuclear receptor subfamily 1 group I member 2; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; Pregnane X receptor; Steroid and xenobiotic receptor; SXR
蛋白名称
Nuclear receptor subfamily 1 group I member 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8856
Human Swissprot No.
O75469
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O75469/entry
Mouse Swissprot No.
O54915
Mouse Swissprot Link
http://www.uniprot.org/uniprot/O54915
免疫原
The antiserum was produced against synthesized peptide derived from human NR1I2. AA range:91-140
特异性
PXR Polyclonal Antibody detects endogenous levels of PXR protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008],
组织表达
Expressed in liver, colon and small intestine.
功能
function:Orphan receptor; its natural ligand is probably pregnane. Binds to a response element in the CYP3A4 and ABCB1/MDR1 genes promoter. Activates its expression in response to a wide variety of endobiotics and xenobiotics.,induction:Activated by naturally occurring steroids such as pregnenolone and progesterone.,similarity:Belongs to the nuclear hormone receptor family. NR1 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,subunit:Forms a heterodimer with RXR.,tissue specificity:Expressed in liver, colon and small intestine.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
