产品名称
PTP IA-2β Rabbit Polyclonal Antibody
别名
PTPRN2; KIAA0387; Receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; Islet cell autoantigen-related protein; IAR; ICAAR; Phogrin
蛋白名称
Receptor-type tyrosine-protein phosphatase N2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5799
Human Swissprot No.
Q92932
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q92932/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19276
Mouse Swissprot No.
P80560
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P80560
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29714
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q63475
免疫原
The antiserum was produced against synthesized peptide derived from human PTPRN2. AA range:206-255
特异性
PTP IA-2β Polyclonal Antibody detects endogenous levels of PTP IA-2β protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015],
组织表达
Highest levels in brain and pancreas (PubMed:8954911, PubMed:8798755). Lower levels in trachea, prostate, stomach and spinal cord (PubMed:8798755).
细胞定位
Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass type I membrane protein . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein . Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N-terminal propeptide domain of the precursor and its interaction with CPE (By similarity). Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin-dependent AP2-mediated endocytosis. Recycled via STX6- but not TTTGN1/TGN38-containing compartments (By similarity). .; [IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane .
信号通路
Type I diabetes mellitus;
功能
catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,disease:Autoantigen in insulin-dependent diabetes mellitus (IDDM).,domain:The cytoplasmic domain appears to contain the autoantigenic epitopes.,function:Implicated in development of nervous system and pancreatic endocrine cells.,PTM:Appears to undergo multiple proteolytic cleavage at consecutive basic residues.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,tissue specificity:Highest levels in brain and pancreas. Lower levels in trachea, prostate, stomach and spinal chord.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
