产品名称
PTGR2 Rabbit Polyclonal Antibody
别名
PTGR2; ZADH1; Prostaglandin reductase 2; PRG-2; 15-oxoprostaglandin 13-reductase; Zinc-binding alcohol dehydrogenase domain-containing protein 1
蛋白名称
Prostaglandin reductase 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=145482
Human Swissprot No.
Q8N8N7
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8N8N7/entry
Mouse Swissprot No.
Q8VDQ1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8VDQ1
免疫原
The antiserum was produced against synthesized peptide derived from human ZADH1. AA range:181-230
特异性
PTGR2 Polyclonal Antibody detects endogenous levels of PTGR2 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
功能
catalytic activity:11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.,cofactor:NADPH.,function:Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.,similarity:Belongs to the NADP-dependent oxidoreductase L4BD family.,subunit:Monomer.,tissue specificity:Widely expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
