BD-PT3887

PSMD12 Rabbit Polyclonal Antibody

PSMD12; 26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit RPN5; 26S proteasome regulatory subunit p55

常规抗体

PSMD12

26S proteasome non-ATPase regulatory subunit 12

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

5718

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5718

O00232

http://www.uniprot.org/uniprotkb/O00232/entry

66997

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66997

Q9D8W5

http://www.uniprot.org/uniprot/Q9D8W5

The antiserum was produced against synthesized peptide derived from human PSMD12. AA range:151-200

PSMD12 Polyclonal Antibody detects endogenous levels of PSMD12 protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

50kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. Alternatively spliced transcript variants encoding

Brain,Muscle,Platelet,Testis,Tongue,

proteasome complex,nucleoplasm,cytoplasm,cytosol,proteasome regulatory particle,proteasome regulatory particle, lid subcomplex,membrane,proteasome accessory complex,nuclear proteasome complex,extracellular exosome,

Proteasome;

function:Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.,similarity:Belongs to the proteasome subunit p55 family.,similarity:Contains 1 PCI domain.,subunit:Component of the PA700 complex.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.