产品名称
PSD-93 Rabbit Polyclonal Antibody
别名
DLG2; Disks large homolog 2; Channel-associated protein of synapse-110; Chapsyn-110; Postsynaptic density protein PSD-93
蛋白名称
Disks large homolog 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1740
Human Swissprot No.
Q15700
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q15700/entry
Mouse Swissprot No.
Q91XM9
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q91XM9
免疫原
The antiserum was produced against synthesized peptide derived from human DLG2. AA range:601-650
特异性
PSD-93 Polyclonal Antibody detects endogenous levels of PSD-93 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008],
组织表达
Brain,Brain cortex,Caudate nucleus,Cerebellum,Retina,
细胞定位
Cell membrane ; Lipid-anchor . Cell junction, synapse, postsynaptic density . Cell junction, synapse . Membrane . Cell projection, axon . Perikaryon . Concentrated in soma and postsynaptic density of a subset of neurons. .
功能
domain:Isoform 2 has an L27 domain close to N-terminus.,function:Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses.,PTM:Palmitoylation of isoform 1 is not required for targeting to postsynaptic density.,similarity:Belongs to the MAGUK family.,similarity:Contains 1 guanylate kinase-like domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 3 PDZ (DHR) domains.,subcellular location:Concentrated in soma and postsynaptic density of a subset of neurons.,subunit:Interacts with NOS1/nNOS through second PDZ domain (By similarity). Interacts with C-terminus of KCNJ2/Kir2.1 through one of its PDZ domains.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
