产品名称
PSCA Rabbit Polyclonal Antibody
别名
PSCA; Prostate stem cell antigen
蛋白名称
Prostate stem cell antigen
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8000
Human Swissprot No.
O43653
Human Swissprot Link
http://www.uniprot.org/uniprotkb/O43653/entry
Mouse Swissprot No.
P57096
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P57096
免疫原
The antiserum was produced against synthesized peptide derived from human Prostate Stem Cell Antigen. AA range:41-90
特异性
PSCA Polyclonal Antibody detects endogenous levels of PSCA protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],
组织表达
Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.
细胞定位
Cell membrane ; Lipid-anchor, GPI-anchor .
功能
function:May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.,induction:Down-regulated in gastric cancer cells.,polymorphism:Genetic variations in PSCA may influence susceptibility to diffuse-type gastric cancer.,similarity:Contains 1 UPAR/Ly6 domain.,tissue specificity:Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level).,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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