产品名称
PRPF31 Rabbit Polyclonal Antibody
别名
PRPF31; PRP31; U4/U6 small nuclear ribonucleoprotein Prp31; Pre-mRNA-processing factor 31; Serologically defined breast cancer antigen NY-BR-99; U4/U6 snRNP 61 kDa protein; Protein 61K; hPrp31
蛋白名称
U4/U6 small nuclear ribonucleoprotein Prp31
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26121
Human Swissprot No.
Q8WWY3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8WWY3/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68988
Mouse Swissprot No.
Q8CCF0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8CCF0
免疫原
The antiserum was produced against synthesized peptide derived from human PRP31. AA range:331-380
特异性
PRPF31 Polyclonal Antibody detects endogenous levels of PRPF31 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009],
组织表达
Ubiquitously expressed.
细胞定位
Nucleus . Nucleus speckle . Nucleus, Cajal body . Predominantly found in speckles and in Cajal bodies. .
功能
disease:Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.,function:Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.,similarity:Contains 1 Nop domain.,subcellular location:Predominantly found in speckles and in Cajal bodies.,subunit:Part of a tri-snRNP complex. Interacts with C20orf14/U5 snRNP-associated 102 kDa protein.,tissue specificity:Ubiquitously expressed.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
