产品名称
PRPF18 Rabbit Polyclonal Antibody
别名
PRPF18; HPRP18; Pre-mRNA-splicing factor 18; PRP18 homolog; hPRP18
蛋白名称
Pre-mRNA-splicing factor 18
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8559
Human Swissprot No.
Q99633
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q99633/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67229
Mouse Swissprot No.
Q8BM39
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BM39
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171552
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q9JKB8
免疫原
The antiserum was produced against synthesized peptide derived from human PRPF18. AA range:182-231
特异性
PRPF18 Polyclonal Antibody detects endogenous levels of PRPF18 protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to the yeast splicing factor Prp18. [provided by RefSeq, Jul 2008],
组织表达
Brain,Cervix carcinoma,Placenta,
细胞定位
Nucleus speckle . Colocalizes with spliceosomal snRNPs. .
功能
function:Participates in the second step of pre-mRNA splicing.,similarity:Belongs to the PRP18 family.,subcellular location:Colocalizes with spliceosomal snRNPs.,subunit:Heterodimer with PPIH. Interacts with PRPF4 and with the spliceosome. Part of a complex containing U4/U6 snRNPs.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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