BD-PT3865

PRP6 Rabbit Polyclonal Antibody

PRPF6; C20orf14; Pre-mRNA-processing factor 6; Androgen receptor N-terminal domain-transactivating protein 1; ANT-1; PRP6 homolog; U5 snRNP-associated 102 kDa protein; U5-102 kDa protein

常规抗体

PRPF6

Pre-mRNA-processing factor 6

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

24148

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24148

O94906

http://www.uniprot.org/uniprotkb/O94906/entry

68879

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=68879

Q91YR7

http://www.uniprot.org/uniprot/Q91YR7

366276

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=366276

A1A5S1

http://www.uniprot.org/uniprot/A1A5S1

The antiserum was produced against synthesized peptide derived from human PRPF6. AA range:747-796

PRP6 Polyclonal Antibody detects endogenous levels of PRP6 protein.

WB 1:500-2000 IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

110kD

-20°C/1 year

Polyclonal, Rabbit,IgG

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing. [provided by RefSeq, Jul 2008],

Widely expressed.

Nucleus, nucleoplasm . Nucleus speckle . Localized in splicing speckles. .

Spliceosome;

function:Involved in pre-mRNA splicing. May act in the tri-snRNP complex as a bridging factor between U5 and U4/U6 snRNPs in the late step of spliceosome assembly. May be necessary for tri-snRNP formation.,similarity:Contains 9 HAT repeats.,subunit:Associates with the U5 snRNP particle (containing the 40 kDa, 52 kDa, 116 kDa, 200 kDa and 220 kDa proteins) probably via interaction(s) with the 220 kDa and/or other proteins. Associates with U4/U6 snRNP particle (containing the 15.5 kDa, 20 kDa/60kDa/90kDa heteromer, LSm proteins LSm2-8, 61 kDa and Sm proteins). Interacts with ARAF1. Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.