产品名称
PRKX Rabbit Polyclonal Antibody
别名
PRKX; PKX1; cAMP-dependent protein kinase catalytic subunit PRKX; PrKX; Protein kinase X; Protein kinase X-linked; Serine/threonine-protein kinase PRKX; Protein kinase PKX1
蛋白名称
cAMP-dependent protein kinase catalytic subunit PRKX
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5613
Human Swissprot No.
P51817
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P51817/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19108
Mouse Swissprot No.
Q922R0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q922R0
免疫原
The antiserum was produced against synthesized peptide derived from human PRKX. AA range:251-300
特异性
PRKX Polyclonal Antibody detects endogenous levels of PRKX protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010],
组织表达
Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982.
细胞定位
Cytoplasm. Nucleus. cAMP induces nuclear translocation.
信号通路
MAPK_ERK_Growth;MAPK_G_Protein;Calcium;Chemokine;Oocyte meiosis;Apoptosis_Inhibition;Apoptosis_Mitochondrial;Apoptosis_Overview;Vascular smooth muscle contraction;WNT;WNT-T CELLHedgehog;Gap junction;Long-term potentiation;Olfactory transduction;Taste tran
功能
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,tissue specificity:High levels in adult and fetal brain, kidney and lung; low levels in adult placenta, heart, liver, skeletal muscle, pancreas and fetal liver.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
