产品名称
LONM Rabbit Polyclonal Antibody
别名
Lon protease homolog, mitochondrial (EC 3.4.21.-) (LONHs) (Lon protease-like protein) (LONP) (Mitochondrial ATP-dependent protease Lon) (Serine protease 15)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.251% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/9361
Human Swissprot No.
P36776
Human Swissprot Link
https://www.uniprot.org/uniprotkb/P36776/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/74142
Mouse Swissprot No.
Q8CGK3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8CGK3
Rat Gene Link
https://www.uniprot.org/uniprot/170916
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q924S5
免疫原
Synthesized peptide derived from human LONM AA range: 398-448
特异性
This antibody detects endogenous levels of LONM at Human/Mouse/Rat
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013],
组织表达
Duodenum, heart, lung and liver, but not thymus.
细胞定位
Mitochondrion matrix .
功能
function:Required for intramitochondrial proteolysis. Catalyzes the initial steps of protein degradation. Hydrolyzes ATP and degrades protein and peptide substrates in an ATP-dependent manner. Binds to single-stranded but not to double-stranded DNA.,similarity:Belongs to the peptidase S16 family.,similarity:Contains 1 Lon domain.,tissue specificity:Duodenum, heart, lung and liver, but not thymus.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
