产品名称
PPP2R3C Rabbit Polyclonal Antibody
别名
PPP2R3C; C14orf10; G5PR; Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma; Protein phosphatase subunit G5PR; Rhabdomyosarcoma antigen MU-RMS-40.6A/6C
蛋白名称
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55012
Human Swissprot No.
Q969Q6
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q969Q6/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=59032
Mouse Swissprot No.
Q9JK24
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JK24
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=362739
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q6AXZ3
免疫原
The antiserum was produced against synthesized peptide derived from human PPP2R3C. AA range:165-214
特异性
PPP2R3C Polyclonal Antibody detects endogenous levels of PPP2R3C protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015],
组织表达
Ubiquitously expressed in brain and other tissues.
细胞定位
Nucleus . Cytoplasm . Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. .
功能
developmental stage:Expressed in fetal brain.,function:May regulate MCM3AP phosphorylation through phosphatase recruitment. May play a role in the activation-induced cell death of B-cells.,similarity:Contains 2 EF-hand domains.,subcellular location:Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis.,subunit:Interacts with MCM3AP/GANP (By similarity). Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A.,tissue specificity:Ubiquitously expressed in brain and other tissues.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
