产品名称
PPP1R14D Rabbit Polyclonal Antibody
别名
PPP1R14D; GBPI; Protein phosphatase 1 regulatory subunit 14D; Gastrointestinal and brain-specific PP1-inhibitory protein 1; GBPI-1
蛋白名称
Protein phosphatase 1 regulatory subunit 14D
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54866
Human Swissprot No.
Q9NXH3
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9NXH3/entry
Mouse Swissprot No.
Q7TT52
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TT52
免疫原
The antiserum was produced against synthesized peptide derived from human PPP1R14D. AA range:66-115
特异性
PPP1R14D Polyclonal Antibody detects endogenous levels of PPP1R14D protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010],
组织表达
Detected in colon, intestine, kidney and brain cortex.
功能
function:Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.,PTM:Phosphorylated on several residues.,similarity:Belongs to the PP1 inhibitor family.,tissue specificity:Detected in colon, intestine, kidney and brain cortex.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
