BD-PK0040

Tubulin α (Acetyl Lys352) Rabbit Polyclonal Antibody

TUBA1A; TUBA3; Tubulin alpha-1A chain; Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain; TUBA1B; Tubulin alpha-1B chain; Alpha-tubulin ubiquitous; Tubulin K-alpha-1; Tubulin alpha-ubiquitous chain; TUBA1C; TUBA6;Tubulin alpha-6 chain; TUBA3C; TUBA2; TUBA3D; Tubulin alpha-3C/D chain; Alpha-tubulin 2; Alpha-tubulin 3C/D; Tubulin alpha-2 chain; TUBA4A; TUBA1; Tubulin alpha-4A chain; Alpha-tubulin 1; Testis-specific alpha-tubulin;

常规抗体

TUBA1A/TUBA1B/TUBA1C/TUBA3C/TUBA4A/TUBA8

Tubulin alpha-1A chain/Tubulin alpha-1B chain/Tubulin alpha-1C chain/Tubulin alpha-3C/D chain/Tubulin alpha-4A chain/Tubulin alpha-8 chain

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

7846

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=7846

Q71U36

http://www.uniprot.org/uniprotkb/Q71U36/entry

22142

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=22142

P68369

http://www.uniprot.org/uniprot/P68369

64158

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64158

P68370

http://www.uniprot.org/uniprot/P68370

The antiserum was produced against synthesized Acetyl-peptide derived from human TUBA1B around the Acetylation site of Lys352. AA range:311-360

Acetyl-Tubulin α (K352) Polyclonal Antibody detects endogenous levels of Tubulin α protein only when acetylated at K352.

WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

50kD

-20°C/1 year

Polyclonal, Rabbit,IgG

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. This gene encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that the gene expression is predominantly found in morphologically differentiated neurologic cells. This gene is one of three alpha-tubulin genes in a cluster on chromosome 12q.

Expressed at a high level in fetal brain.

Cytoplasm, cytoskeleton.

Gap junction;Pathogenic Escherichia coli infection;

disease:Defects in TUBA1A are the cause of lissencephaly type 3 (LIS3) [MIM:611603]. LIS is characterized by a smooth brain surface due to the absence (agyria) or reduction (pachygyria) of surface convolutions. It is often associated with psychomotor retardation and seizures. LIS3 features include agyria or pachygyria or laminar heterotopia, severe mental retardation, motor delay, variable presence of seizures, and abnormalities of corpus callosum, hippocampus, cerebellar vermis and brainstem.,function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,PTM:Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains.,tissue specificity:Expressed at a high level in fetal brain.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.