产品名称
PP2Cκ Rabbit Polyclonal Antibody
别名
PPM1K; PP2CM; Protein phosphatase 1K; mitochondrial; PP2C domain-containing protein phosphatase 1K; PP2C-like mitochondrial protein; PP2C-type mitochondrial phosphoprotein phosphatase; PTMP; Protein phosphatase 2C isoform kappa; PP2C-kappa
蛋白名称
Protein phosphatase 1K mitochondrial
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=152926
Human Swissprot No.
Q8N3J5
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8N3J5/entry
Mouse Swissprot No.
Q8BXN7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BXN7
免疫原
The antiserum was produced against synthesized peptide derived from human PPM1K. AA range:205-254
特异性
PP2Cκ Polyclonal Antibody detects endogenous levels of PP2Cκ protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012],
组织表达
Amygdala,Cerebellum,Lymph node,Pancreas,Testis,
细胞定位
Mitochondrion matrix .
功能
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,caution:Ref.9 has crystallized PPM1K in the presence of magnesium ions. However, PubMed:17336929 reported that no activity toward p-nitrophenylphosphate was seen in the absence of manganese ions and magnesium could not subsitute for manganese.,cofactor:Binds 1 magnesium or manganese ion per subunit.,function:Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
