产品名称
PP2Cε Rabbit Polyclonal Antibody
别名
PPM1L; PP2CE; Protein phosphatase 1L; Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon; PP2C-epsilon
蛋白名称
Protein phosphatase 1L
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=151742
Human Swissprot No.
Q5SGD2
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q5SGD2/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=242083
Mouse Swissprot No.
Q8BHN0
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8BHN0
免疫原
The antiserum was produced against synthesized peptide derived from human PPM1L. AA range:119-168
特异性
PP2Cε Polyclonal Antibody detects endogenous levels of PP2Cε protein.
稀释度
WB 1:500-2000;IHC-p 1:50-300
宿主
Polyclonal, Rabbit,IgG
背景介绍
The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015],
组织表达
Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.
细胞定位
Membrane ; Single-pass type I membrane protein .
功能
catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 2 magnesium or manganese ions per subunit.,function:Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.,similarity:Belongs to the PP2C family.,similarity:Contains 1 PP2C-like domain.,subunit:Interacts with MAP3K7/TAK1 (By similarity). Interacts with MAP3K5.,tissue specificity:Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
