产品名称
PP2A-Aβ Rabbit Polyclonal Antibody
别名
PPP2R1B; Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform; PP2A subunit A isoform PR65-beta; PP2A subunit A isoform R1-beta
蛋白名称
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5519
Human Swissprot No.
P30154
Human Swissprot Link
http://www.uniprot.org/uniprotkb/P30154/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=73699
Mouse Swissprot No.
Q7TNP2
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q7TNP2
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=315648
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q4QQT4
免疫原
The antiserum was produced against synthesized peptide derived from human PPP2R1B. AA range:552-601
特异性
PP2A-Aβ Polyclonal Antibody detects endogenous levels of PP2A-Aβ protein.
稀释度
WB 1:500 - 1:2000.IHC-p:1:50-300 ELISA: 1:20000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010],
细胞定位
membrane raft,extracellular exosome,
信号通路
Oocyte meiosis;WNT;WNT-T CELLTGF-beta;Tight junction;Long-term depression;
功能
disease:Defects in PPP2R1B might be a cause of some lung and colorectal cancers.,domain:Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.,function:The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.,sequence caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Belongs to the phosphatase 2A regulatory subunit A family.,similarity:Contains 15 HEAT repeats.,subunit:PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with SGOL1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
