产品名称
POM121 Rabbit Polyclonal Antibody
别名
POM121; KIAA0618; NUP121; POM121A; Nuclear envelope pore membrane protein POM 121; Nuclear envelope pore membrane protein POM 121A; Nucleoporin Nup121; Pore membrane protein of 121 kDa; POM121B; Putative nuclear envelope pore membrane prote
蛋白名称
Nuclear envelope pore membrane protein POM 121
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9883
Human Swissprot No.
Q96HA1/A6NF01/A8CG34
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q96HA1/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=107939
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=113975
Rat Swissprot Link
http://www.uniprot.org/uniprot/P52591
免疫原
The antiserum was produced against synthesized peptide derived from human POM121. AA range:1197-1246
特异性
POM121 Polyclonal Antibody detects endogenous levels of POM121 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013],
组织表达
Brain,Cervix,Lymph,Skin,Teratocarcinoma,Testis,Uterus,
细胞定位
Nucleus, nuclear pore complex . Nucleus membrane ; Single-pass membrane protein . Endoplasmic reticulum membrane ; Single-pass membrane protein . Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase. .
功能
domain:Contains F-X-F-G repeats.,function:Essential component of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane. When overexpressed in cells induces the formation of cytoplasmic annulate lamellae (AL).,similarity:Belongs to the POM121 family.,subcellular location:Stably associated with the NPC throughout interphase and the endoplasmic reticulum during metaphase.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
