BD-PT3811

POLR2E Rabbit Polyclonal Antibody

POLR2E; DNA-directed RNA polymerases I; II, and III subunit RPABC1; RNA polymerases I, II, and III subunit ABC1; DNA-directed RNA polymerase II 23 kDa polypeptide; DNA-directed RNA polymerase II subunit E; RPB5 homolog; XAP4

常规抗体

POLR2E

DNA-directed RNA polymerases I, II, and III subunit RPABC1

WB

Human,Mouse,Rat

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.

5434

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5434

P19388

http://www.uniprot.org/uniprotkb/P19388/entry

66420

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66420

Q80UW8

http://www.uniprot.org/uniprot/Q80UW8

690966

http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=690966

B0BNE2

http://www.uniprot.org/uniprot/B0BNE2

The antiserum was produced against synthesized peptide derived from human RPAB1. AA range:21-70

POLR2E Polyclonal Antibody detects endogenous levels of POLR2E protein.

WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

25kD

-20°C/1 year

Polyclonal, Rabbit,IgG

This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],

Lung,

Nucleus .

Purine metabolism;Pyrimidine metabolism;RNA polymerase;Huntington's disease;

function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.,PTM:The N-terminus is blocked.,similarity:Belongs to the archaeal rpoH/eukaryotic RPB5 RNA polymerase subunit family.,subunit:Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively (By similarity). In RNA Pol II, this subunit is present in 2-fold molar excess over the other subunits. Interacts with RMP. Interacts with HBV protein X.,

现货

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.