产品名称
POLR1E Rabbit Polyclonal Antibody
别名
POLR1E; PAF53; PRAF1; DNA-directed RNA polymerase I subunit RPA49; RNA polymerase I subunit A49; DNA-directed RNA polymerase I subunit E; RNA polymerase I-associated factor 1; RNA polymerase I-associated factor 53
蛋白名称
DNA-directed RNA polymerase I subunit RPA49
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=64425
Human Swissprot No.
Q9GZS1
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q9GZS1/entry
Mouse Swissprot No.
Q8K202
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q8K202
免疫原
Synthesized peptide derived from the Internal region of human POLR1E.
特异性
POLR1E Polyclonal Antibody detects endogenous levels of POLR1E protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200
宿主
Polyclonal, Rabbit,IgG
背景介绍
function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF.,similarity:Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.,subunit:Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity). Interacts with PAF49/CD3EAP. Also binds UBTF/UBF.,
组织表达
Cervix,Lung,Placenta,
细胞定位
Nucleus, nucleolus .
信号通路
Purine metabolism;Pyrimidine metabolism;RNA polymerase;
功能
function:DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF.,similarity:Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.,subunit:Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity). Interacts with PAF49/CD3EAP. Also binds UBTF/UBF.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
