产品名称
PLC β3 Rabbit Polyclonal Antibody
别名
PLCB3; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase beta-3; Phosphoinositide phospholipase C-beta-3; Phospholipase C-beta-3; PLC-beta-3
蛋白名称
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5331
Human Swissprot No.
Q01970
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q01970/entry
Mouse Swissprot No.
P51432
Mouse Swissprot Link
http://www.uniprot.org/uniprot/P51432
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q99JE6
免疫原
The antiserum was produced against synthesized peptide derived from human PLC beta3. AA range:503-552
特异性
PLC β3 Polyclonal Antibody detects endogenous levels of PLC β3 protein.
稀释度
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
宿主
Polyclonal, Rabbit,IgG
背景介绍
This gene encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010],
细胞定位
Cytoplasm . Membrane . Nucleus . And particulate fractions. .
信号通路
Stem cell pathway; WNT;WNT-T CELL;β-Catenin; AMPK
功能
catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Calcium.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,subunit:Interacts with SHANK2 (By similarity). Interacts with LPAR2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
