产品名称
PKR1 Rabbit Polyclonal Antibody
别名
PROKR1; GPR73; PKR1; Prokineticin receptor 1; PK-R1; G-protein coupled receptor 73; G-protein coupled receptor ZAQ; GPR73a
蛋白名称
Prokineticin receptor 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10887
Human Swissprot No.
Q8TCW9
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q8TCW9/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58182
Mouse Swissprot No.
Q9JKL1
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q9JKL1
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=192648
Rat Swissprot Link
http://www.uniprot.org/uniprot/Q8R416
免疫原
The antiserum was produced against synthesized peptide derived from human PKR1. AA range:19-68
特异性
PKR1 Polyclonal Antibody detects endogenous levels of PKR1 protein.
稀释度
WB 1:500-2000; IF ICC 1:100-500;ELISA 1:5000-20000;IHC-p 1:100-500
宿主
Polyclonal, Rabbit,IgG
背景介绍
prokineticin receptor 1(PROKR1) Homo sapiens This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016],
组织表达
Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas.
细胞定位
Cell membrane; Multi-pass membrane protein.
功能
function:Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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