产品名称
PLC β2 Rabbit Polyclonal Antibody
别名
PLCB2; 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase beta-2; Phosphoinositide phospholipase C-beta-2; Phospholipase C-beta-2; PLC-beta-2
蛋白名称
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5330
Human Swissprot No.
Q00722
Human Swissprot Link
http://www.uniprot.org/uniprotkb/Q00722/entry
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=18796
Mouse Swissprot No.
A3KGF7
Mouse Swissprot Link
http://www.uniprot.org/uniprot/A3KGF7
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=85240
Rat Swissprot Link
http://www.uniprot.org/uniprot/O89040
免疫原
Synthesized peptide derived from the Internal region of human PLC β2.
特异性
PLC β2 Polyclonal Antibody detects endogenous levels of PLC β2 protein.
宿主
Polyclonal, Rabbit,IgG
背景介绍
catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Binds 1 calcium ion per subunit.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,miscellaneous:The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,subunit:Interacts with RAC1.,
组织表达
Placenta,Spleen,Thymus,
细胞定位
intracellular,cytosol,
信号通路
Stem cell pathway; WNT;WNT-T CELL;β-Catenin; AMPK
功能
catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.,cofactor:Binds 1 calcium ion per subunit.,function:The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.,miscellaneous:The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha-16.,similarity:Contains 1 C2 domain.,similarity:Contains 1 PI-PLC X-box domain.,similarity:Contains 1 PI-PLC Y-box domain.,subunit:Interacts with RAC1.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
